With the GeoMx® DSP, we can profile up to 22,000 genes simultaneously and generate highly multiplexed, spatially resolved gene expression data from a single tissue sample. This cutting-edge technology allows us to map gene expression patterns within a tissue sample and analyze the spatial distribution of specific cell types, providing valuable insights into the underlying biological processes.
Why go spatial?
Bulk sequencing provides a snapshot of the average gene expression across all the cells in a sample. However, it does not provide information about the spatial organization of those cells or the specific cell types that are present in the region of biological interest. In contrast, spatial biology profiling techniques can identify the location of individual cell/or group of cells and provide a detailed information of the gene/protein expression patterns within each cell/group of cells and its surrounding environment. This is particularly important in the study of complex diseases such as cancer, neuro-disorder and other tissue based changes, where cellular heterogeneity and spatial organization play a critical role in disease progression and treatment response.
Co-detection with protein
Spatial Biology provides best of both worlds : Spatial resolution and highplex profiling
How it works?
The GeoMx® DSP system operates by smoothly integrating with existing histology or genomics workflows, enabling researchers to swiftly acquire dependable and replicable spatial multiomics data. By utilizing whole tissue sections, whether they are FFPE or fresh frozen, RNA or protein staining can be performed. Following this, researchers can accurately identify which tissue compartments or cell types to profile, based on the biological context, and quantify the expression levels either via the nCounter® Analysis System or an Illumina Sequencer.
Locate Your Regions of Interest : Understand Tissue Structure with Flexibilty
Profile with any geometric shape to characterize distinct tissue regions.
Identify and profile distinct biological compartments within a region of interest (ROI).
Evaluate how proximity affects biological response and the local micro environment using radiating ROIs.
Perform rigorous spatial mapping using a tunable grid pattern. Gain comprehensive information.
Cell Type Specific Profiling
Reveal the function of cell populations guided by cell type specific morphology markers.
Why choose theraCUES
theraCUES is the first in India to provide GeoMx® solutions. Being the leader in India we have understood the intricacies of spatial biology experiments from planning till analysis. We provide you the best solutions based on the project needs and our learnings.
Any spatial Biology experiment involves extensive planning right from tissue selection to visualising the results, theraCUES team helps you in every step to reach the goal of the project.
Expertise in working with various research/clinical tissue samples i.e FFPE, Fresh frozen, and different types of biopsy samples.
Enhanced customer experience through regular project status update and agreed TAT.
Spatial phenotyping of the scRNA-Seq data is made possible!
Characterize the cell type within which the spatial biomarker is distinctly expressed.
Spatial Pathway Analysis.
Characterize spatially the ligand-receptor interaction for any tissue.
Find the co-expressed cell types
Deconvolute or profile the abundance of any cell type specific to your tissue/disease of interest using the multiOMIC approach of plugging in scRNASeq data.